Executive Order to Strengthen U.S. Pharmaceutical Supply Chain via Strategic Active Pharmaceutical Ingredients Reserve (SAPIR)
Impact Score: 3.8
Timeline: Implementation underway from August 13, 2025, with key milestones across 30 days to 1 year
Summary: This Executive Order aims to enhance the resilience of the U.S. pharmaceutical supply chain by expanding domestic production and stockpiling of Active Pharmaceutical Ingredients (APIs) through the Strategic Active Pharmaceutical Ingredients Reserve (SAPIR). Central to the order are timelines for ASPR to develop critical drug lists, prepare SAPIR repositories, and maintain a six-month API supply favoring domestic sources. It involves federal agencies like HHS and OMB, impacts Vanderbilt University programs and funding opportunities, and requires substantial coordination and investment to ensure reliable pharmaceutical access and national health security.
Key Actions: Vanderbilt should pursue partnerships with pharmaceutical manufacturers, align research programs with SAPIR goals, advocate for funding, and engage in healthcare policy research to support the domestic API initiative.
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